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Dynamics of extracellular glutamate (DECG)

Objective

Glutamate (Glue) is the major mediator of excitatory signals in the central nervous system and both too low and too high levels of Glue are harmful. Glue exerts its signalling function by activating receptors on the cell surfaces. Nervous tissue is an extremely complex network of cellular extensions. Glue receptors are widely distributed within this network; both within and outside synapses. Glue is released at synapses and from other parts of both neurons and supporting cells. Understanding of Glue mediated signalling therefore requires insight into how Glue diffuses between the cellular elements and how it is released into and is removed from the extra cellular fluid. Disturbance of this control likely contributes to several disorders causing suffering and economic losses. The consortium will clarify the mechanisms controlling extra cell. Glue, and will produce a knowledge base for pharmaceutical industry and clinical medicine.

Call for proposal

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Coordinator

UNIVERSITY OF OSLO
Address
Sognsvannsveien 9
0317 Oslo
Norway

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Participants (5)

CELICA D.O.O.
Slovenia
Address
Stegne 21
1000 Ljubljana

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FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Address
Via Olgettina 58
20132 Milano

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UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London

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UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Queen Square
WC1N 3BG London

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UNIVERSITY OF LAUSANE
Switzerland
Address
9,rue Du Bugnon 9
1005 Lausanne

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