Kainate and ampa receptor trafficking and recycling at brain synapses (KAR-TRAP)

Objective

Glutamate receptors are replicated in important neurological diseases and believed to play central roles in brain development, learning and memory. With their associated intracellular signalling molecules, they attract considerable interest is potential therapeutically targets in neurological conditions such as stroke, chronic neurodegenerative diseases, Alzheimer’s disease, and schizophrenia. These are major health problems, particularly among elderly, that strongly call for new therapeutic approaches. The present project intends to provide an experimental basis for development of therapies that act by reducing or increasing the number of glutamate receptors at the synapse. Specifically, attempts will be made to resolve the mechanisms underlying insertion into and removal of glutamate receptors from somatic membranes. This may reveal molecular targets for fine-tuning of synaptic transmission in specific brain areas.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-9. - Neurosciences

Funding Scheme

Coordinator

Participants (3)