Objective
Glutamate receptors are replicated in important neurological diseases and believed to play central roles in brain development, learning and memory. With their associated intracellular signalling molecules, they attract considerable interest is potential therapeutically targets in neurological conditions such as stroke, chronic neurodegenerative diseases, Alzheimers disease, and schizophrenia. These are major health problems, particularly among elderly, that strongly call for new therapeutic approaches. The present project intends to provide an experimental basis for development of therapies that act by reducing or increasing the number of glutamate receptors at the synapse. Specifically, attempts will be made to resolve the mechanisms underlying insertion into and removal of glutamate receptors from somatic membranes. This may reveal molecular targets for fine-tuning of synaptic transmission in specific brain areas.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- natural sciencesbiological sciencescell biologycell signaling
- medical and health sciencesbasic medicineneurologystroke
- medical and health sciencesclinical medicinepsychiatryschizophrenia
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Topic(s)
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
0317 OSLO
Norway