The long-term goal of this proposal is to understand how the cerebellum functions. Our approach is based on a tight interaction between computer modelling and experimental work.
The work is organized around five scientific questions:
- cerebella connections: what is the relation between in sag tally oriented microtones and the patchy maps of mossy fibber projections?
- Functional organization of the climbing fibber system:
does it strictly follow the capital microtones and can inhibition from deep cerebella nuclei uncouple livery neurons?
- What is the physiological role of synaptic plasticity at the mossy fibbers to granule cell synapse?
- What is the function of the glomeruli in the cerebella granular layer?
- How does plasticity of parallel fibber synapses affect Purkinje cell firing and what is its relation to motor learning? In addition we will develop web accessible neuroinformatics database on the cerebellum and organize yearly scientific meetings.
Funding SchemeCSC - Cost-sharing contracts
3000 DR Rotterdam