Skip to main content

Computation and plasticity in the cerebellar system: experiments, modeling and database (CEREBELLUM)

Objective

The long-term goal of this proposal is to understand how the cerebellum functions. Our approach is based on a tight interaction between computer modelling and experimental work.
The work is organized around five scientific questions:
- cerebella connections: what is the relation between in sag tally oriented microtones and the patchy maps of mossy fibber projections?
- Functional organization of the climbing fibber system:
does it strictly follow the capital microtones and can inhibition from deep cerebella nuclei uncouple livery neurons?
- What is the physiological role of synaptic plasticity at the mossy fibbers to granule cell synapse?
- What is the function of the glomeruli in the cerebella granular layer?
- How does plasticity of parallel fibber synapses affect Purkinje cell firing and what is its relation to motor learning? In addition we will develop web accessible neuroinformatics database on the cerebellum and organize yearly scientific meetings.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITAIRE INSTELLING ANTWERPEN - UNIVERSITEIT ANTWERPEN
Address
Universiteitsplein 1
2610 Wilrijk (Antwerpen)
Belgium

Participants (5)

ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
Address
Dr Molewaterplein 51
3000 DR Rotterdam
ITALIAN INSTITUTE FOR THE PHYSICS OF MATTER
Italy
Address
Via Forlanini 6
27100 Pavia
THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORITY FOR RESEARCH AND DEVELOPMENT
Israel
Address
Edmond Safra Campus, Givat Ram
91904 Jerusalem
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
UNIVERSITY OF OSLO
Norway
Address
Sognsvannsveien 9
0317 Oslo