Objective
Despite perception of Ecstasy as a "safe drug", its neurotoxicity to 5-HT neurones suggests that users may suffer CNS dysfunctions involving 5-HT (emotion, mood, drive and self-control, sleep, pain, cognitive processes), leading to possible occurrence of neurological and/or psychiatric diseases later in life. Our objective is to advance the knowledge of cellular and molecular mechanisms involving the 5-HT system in Ecstasy-induced CNS damage and subsequent abnormal repair. The work will focus on%l1) the development of relevant animal models for assessing the effects of Ecstasy under conditions closely resembling those in human users;
2) analyses of cellular mechanisms of acute and long-term Ecstasy action and toxicity;
3) characterization of Ecstasy- induced damage and long-term consequences on neurotransmission, cerebral blood flow and metabolism, and cognitive performances;
4) evaluation of the potential of antidepressant drugs in preventing and/or reducing Ecstasy-induced damage.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
50139 FIRENZE
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.