Objective The goal of this project is to elucidate novel molecular and cellular mechanisms of nervous system development and repair using the paradigm of the GDNF family offloads and their receptors. GDNF is a potent growth factor for various central and peripheral neurons and has received much attention as a potential therapeutic agent for the treatment of neurodegenerative diseases. Our strategy is to address crucial gaps in the understanding of the role of GDNF legends in neuronal development, function and repair, with the confident expectation that this will reveal new principles of neurodevelopment and neuroprotection of general applicability. To this end, we propose to integrate studies on novel GDNF signalling receptors, GDNF target genes, novel tissue-specific knock-out and transgenic models, development of peripheral and central neural stem cells, and mechanistic bases of neuroprotection in stroke and Parkinson's disease models. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurologystrokemedical and health sciencesbasic medicineneurologyparkinson Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-9. - Neurosciences Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator KAROLINSKA INSTITUTE Address Retzius vaeg 8 171 77 Stockholm Sweden See on map EU contribution € 0,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all LUND UNIVERSITY Sweden EU contribution € 0,00 Address Sölvegatan 17 221 84 Lund See on map MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 0,00 Address The ridgeway, mill hill NW7 1AA London See on map NATIONAL RESEARCH COUNCIL OF ITALY Italy EU contribution € 0,00 Address Via guglielmo marconi 10 80125 Napoli See on map NSGENE A/S Denmark EU contribution € 0,00 Address Pederstrupvej 93 2750 Ballerup See on map UNIVERSITY OF HELSINKI Finland EU contribution € 0,00 Address 9,viikinkaari 9 biocentre 1a 00014 Helsinki See on map
