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Trophic signaling by gdnf family ligands and their receptors in neuronal development and repair (GDNF)

Objective

The goal of this project is to elucidate novel molecular and cellular mechanisms of nervous system development and repair using the paradigm of the GDNF family offloads and their receptors. GDNF is a potent growth factor for various central and peripheral neurons and has received much attention as a potential therapeutic agent for the treatment of neurodegenerative diseases. Our strategy is to address crucial gaps in the understanding of the role of GDNF legends in neuronal development, function and repair, with the confident expectation that this will reveal new principles of neurodevelopment and neuroprotection of general applicability. To this end, we propose to integrate studies on novel GDNF signalling receptors, GDNF target genes, novel tissue-specific knock-out and transgenic models, development of peripheral and central neural stem cells, and mechanistic bases of neuroprotection in stroke and Parkinson's disease models.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KAROLINSKA INSTITUTE
Address
Retzius Vaeg 8
171 77 Stockholm
Sweden

Participants (5)

LUND UNIVERSITY
Sweden
Address
Sölvegatan 17
221 84 Lund
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
The Ridgeway, Mill Hill
NW7 1AA London
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Via Guglielmo Marconi 10
80125 Napoli
NSGENE A/S
Denmark
Address
Pederstrupvej 93
2750 Ballerup
UNIVERSITY OF HELSINKI
Finland
Address
9,Viikinkaari 9 Biocentre 1A
00014 Helsinki