Objective
Proposal aim is to identify novel targets for pharmacological treatment of alcoholism. In an integrative approach, complementary expertise of 5 laboratories is applied. Pharmacologically validated animal models are adapted for generation of tissue from key brain regions. RNA is purified, and gene expression profiles established using Affymetrix methodology. An expression database is constructed, and mining the database identifies candidate genes differentially expressed in the functional models. Candidates are prioritised on the basis of available knowledge and availability of pharmacological tools, and confirmed using real time PCR and in site hybridisation. Confirmed targets are fed back into the functional models, where pharmacological and molecular manipulations of targets are evaluated for their ability to block alcohol drinking and reinstatement. Validated targets are patented and provide seeds for drug development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences computer and information sciences databases
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
141 86 HUDDINGE
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.