The most remarkable feature of the Central Nervous System (CNS) is the massive array of neurons that permit the diversity of functional neuronal circuits. The spinal cord contains neurons that integrate and relay sensory information from the periphery to the brain and the neurons that control and co-ordinate motor output. Mature neurons derive from neuronal progenitors that appear in a highly patio-temporal order in different neural regions. A major question in developmental neurobiology is to understand how the developing neural tube becomes patterned into distinct clusters of neuronal progenitors. A second, equally important, issue is to define the genetic mechanisms that govern cell fate determination and subtype specification of cells in the same progenitor pool. The latter question is of important relevance to stem cell therapy for neurodegenerative disorders of the brain and spinal cord.
Funding SchemeCSC - Cost-sharing contracts
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