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Genetic mechanisms that determine neuronal progenitor identity in the ventral spinal cord (STEMBRIDGE)

Objective

The most remarkable feature of the Central Nervous System (CNS) is the massive array of neurons that permit the diversity of functional neuronal circuits. The spinal cord contains neurons that integrate and relay sensory information from the periphery to the brain and the neurons that control and co-ordinate motor output. Mature neurons derive from neuronal progenitors that appear in a highly patio-temporal order in different neural regions. A major question in developmental neurobiology is to understand how the developing neural tube becomes patterned into distinct clusters of neuronal progenitors. A second, equally important, issue is to define the genetic mechanisms that govern cell fate determination and subtype specification of cells in the same progenitor pool. The latter question is of important relevance to stem cell therapy for neurodegenerative disorders of the brain and spinal cord.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS
Address
International Airport Avenue, No.6
1683 Nicosia
Cyprus

Participants (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Jordi Girona, 18/26
08034 Barcelona
KAROLINSKA INSTITUTE
Sweden
Address
Von Eulers Vag 3
171 77 Stockholm
KING'S COLLEGE LONDON
United Kingdom
Address
De Crespigny Park, Denmark Hill
SE5 8AF London
MRC National Institute for Medical Research
United Kingdom
Address
The Ridgeway Mill Hill
NW7 1AA London
UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA
Italy
Address
Piazza Della Scienza 2
20126 Milano