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The genetic and neurobiological basis of x-linked mental retardation (euro-mrx).

Objective

With a prevalence of about 2%, mental retardation (MR) poses an important medical and socio-economic problem. The European MRX Consortium has been instrumental in characterizing families with non-specific X-linked MR (MRX) and cloning most of the MRX genes, with two objectives:
(1) increasing the possibilities for genetic counselling for MR (X) and
(2) elucidation of the neurobiological mechanisms underlying MR, to create a basis for therapeutic intervention. Using neuronal tissue cultures and genetically modified mice we will study the biological mechanisms which link MRX gene defects to deficient cognitive functioning in humans. In addition, cloning of additional MRX genes will be accelerated using highly innovative approaches. These studies will greatly enhance our understanding of the cellular basis of cognition.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
10,Geert Grooteplein 10
6500 HB Nijmegen
Netherlands

Participants (7)

CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS
Cyprus
Address
International Airport Avenue, No.6
2370 Nicosia
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
C/o Faculte De Medecine, Boulevard Tonnelle, 2 Bis
37032 Tours
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue Du General Sarrail, 8
94010 Creteil
KAROL MARCINKOWSKI UNIVERSITY OF MEDICAL SCIENCES - ACADEMY OF MEDICINE
Poland
Address
Ul. Szpitalna, 27/30
60 572 Poznan
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
49,Herestraat 49
3000 Louvain / Leuven
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Ihnestrasse 73
14195 Berlin
ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCE
Netherlands
Address
Meibergdreef 33
1105 AZ Amsterdam