Gapers constitute one of the largest families of neurotransmitter and hormone receptors. They represent 1 to 3% of the human genome (more than 1000 genes) and the most important neuronal and hormonal signal transudation system. Gapers display a common 7 Tran membrane spanning domain, but use a surprisingly wide variety of recognition molecules, signalling cascades and cellular targets. Because of such diversity, they are involved in a large number of physic-pathological functions and are the major target of therapeutic drugs. This diversity in signalling mechanisms and functions of Gapers increased even more during the last 10 years of research. The aim of this proposal is to organise a European workshop focused on the latest and most important discoveries on Gapers, in order to update our knowledge in the field. This may also help us to re-orient our ongoing European project related to glutamates Gapers and epilepsy (QLRT-2000-00929).