Early clinical diagnosis of human spongiform encephalopathies by analysis of biological fluids (CJD MARKERS)

Objective

The introduction of biochemical parameters (proteins such as 14-3-3, NSE, S 100 and taut) has led to the improvement of the clinical 1 diagnosis of CJD. In the differential diagnosis of neurodegenerative disorders, elevated levels in the cerebrospinal fluid (CSF) support the diagnosis with sensitivity and specificity of and 93%. However, some disease phenotypes (such as variant CJD, sporadic CJD with MV-2 phenotype and genetic cases) are negative for, those parameters. The proposed study will cover the work on further biochemical parameters (surrogate markers) of the disease. A set of parameters for early diagnosis during lifetime will be established. Another aspect of the proposed study will cover the detection methodology of disease-specific infected protein in biological fluids such as CSF, serum, plasma and urine using capillary electrophoresis. A sample bank from patients with CJD, other dementia and normal controls will be established.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-9. - Neurosciences

Funding Scheme

CON - Coordination of research actions

Coordinator

FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN

Address

Robert-koch-strasse 40
37075 Goettingen
Germany

Participants (9)

CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS

Greece

Address

Charilaou 6Th Km - Thermi Road
57001 Thermi

ERASMUS UNIVERSITEIT ROTTERDAM

Netherlands

Address

50,Dr. Molewaterplein 50
3015 GE Rotterdam

HOSPITAL CLINIC BARCELONA

Spain

Address

Calle Villaroel 170
08036 Barcelona

INSTITUTE OF HEALTH CARLOS III

Spain

Address

Carretera De Majadahonda - Pozuelo Km.2
28220 Majadahonda

INSTITUTE OF PREVENTIVE AND CLINICAL MEDICINE

Slovakia

Address

Limbova 14
833 01 Bratislava

INSTITUTE OF PSYCHIATRY AND NEUROLOGY

Poland

Address

Sobieskiego 1/9
02 957 Warszawa

ISTITUTO SUPERIORE DI SANITA

Italy

Address

Viale Regina Elena 299
00161 Roma

THE UNIVERSITY OF MELBOURNE

Australia

Address

Grahan Street
3010 Parkville Victoria

UNIVERSITY HOSPITAL OF ZUERICH

Switzerland

Address

Frauenklinikstr. 26
8091 Zurich