Objective
The introduction of biochemical parameters (proteins such as 14-3-3, NSE, S 100 and taut) has led to the improvement of the clinical 1 diagnosis of CJD. In the differential diagnosis of neurodegenerative disorders, elevated levels in the cerebrospinal fluid (CSF) support the diagnosis with sensitivity and specificity of and 93%. However, some disease phenotypes (such as variant CJD, sporadic CJD with MV-2 phenotype and genetic cases) are negative for, those parameters. The proposed study will cover the work on further biochemical parameters (surrogate markers) of the disease. A set of parameters for early diagnosis during lifetime will be established. Another aspect of the proposed study will cover the detection methodology of disease-specific infected protein in biological fluids such as CSF, serum, plasma and urine using capillary electrophoresis. A sample bank from patients with CJD, other dementia and normal controls will be established.
Topic(s)
Call for proposal
Data not availableFunding Scheme
CON - Coordination of research actionsCoordinator
37075 Goettingen
Germany
Participants (9)
57001 Thermi
3015 GE Rotterdam
08036 Barcelona
28220 Majadahonda
833 01 Bratislava
02 957 Warszawa
00161 Roma
3010 Parkville Victoria
8091 Zurich