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Early clinical diagnosis of human spongiform encephalopathies by analysis of biological fluids (CJD MARKERS)

Objective

The introduction of biochemical parameters (proteins such as 14-3-3, NSE, S 100 and taut) has led to the improvement of the clinical 1 diagnosis of CJD. In the differential diagnosis of neurodegenerative disorders, elevated levels in the cerebrospinal fluid (CSF) support the diagnosis with sensitivity and specificity of and 93%. However, some disease phenotypes (such as variant CJD, sporadic CJD with MV-2 phenotype and genetic cases) are negative for, those parameters. The proposed study will cover the work on further biochemical parameters (surrogate markers) of the disease. A set of parameters for early diagnosis during lifetime will be established. Another aspect of the proposed study will cover the detection methodology of disease-specific infected protein in biological fluids such as CSF, serum, plasma and urine using capillary electrophoresis. A sample bank from patients with CJD, other dementia and normal controls will be established.

Funding Scheme

CON - Coordination of research actions

Coordinator

FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN
Address
Robert-koch-strasse 40
37075 Goettingen
Germany

Participants (9)

CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS
Greece
Address
Charilaou 6Th Km - Thermi Road
57001 Thermi
ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
Address
50,Dr. Molewaterplein 50
3015 GE Rotterdam
HOSPITAL CLINIC BARCELONA
Spain
Address
Calle Villaroel 170
08036 Barcelona
INSTITUTE OF HEALTH CARLOS III
Spain
Address
Carretera De Majadahonda - Pozuelo Km.2
28220 Majadahonda
INSTITUTE OF PREVENTIVE AND CLINICAL MEDICINE
Slovakia
Address
Limbova 14
833 01 Bratislava
INSTITUTE OF PSYCHIATRY AND NEUROLOGY
Poland
Address
Sobieskiego 1/9
02 957 Warszawa
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma
THE UNIVERSITY OF MELBOURNE
Australia
Address
Grahan Street
3010 Parkville Victoria
UNIVERSITY HOSPITAL OF ZUERICH
Switzerland
Address
Frauenklinikstr. 26
8091 Zurich