Objective
The introduction of biochemical parameters (proteins such as 14-3-3, NSE, S 100 and taut) has led to the improvement of the clinical 1 diagnosis of CJD. In the differential diagnosis of neurodegenerative disorders, elevated levels in the cerebrospinal fluid (CSF) support the diagnosis with sensitivity and specificity of and 93%. However, some disease phenotypes (such as variant CJD, sporadic CJD with MV-2 phenotype and genetic cases) are negative for, those parameters. The proposed study will cover the work on further biochemical parameters (surrogate markers) of the disease. A set of parameters for early diagnosis during lifetime will be established. Another aspect of the proposed study will cover the detection methodology of disease-specific infected protein in biological fluids such as CSF, serum, plasma and urine using capillary electrophoresis. A sample bank from patients with CJD, other dementia and normal controls will be established.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine neurology dementia
- natural sciences chemical sciences electrochemistry electrophoresis
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
37075 GOETTINGEN
Germany
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