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Investigating the role of oxidative stress or diet on prion disease susceptibility

Objective

PrPc binds copper and has antioxidant activity enhancing the survival of cells in culture, suggesting that PrPSc accumulation may lead to an aberrant copper metabolism altering the cellular redox state. This proposal centres on understanding to what extend PrPc expression, and susceptibility to prion can be influenced by oxidative stress. In vitro studies with murine neuroblastoma N2a and Schwann MSC80A cells, and in vivo studies with transgenic mice over expressing either mice, human or bovine PrPc, under normal conditions or after various treatments (irradiation, hypoxia, Cu depletion and Mn feeding, ingestion of phosmet) known to cause oxidative stress, will show if and to what extent these stress situations may enhance PrPc expression and the susceptibility to prion infection. The work will also contribute to the basic understanding of PrP and may give information or cellular tools (new chronically infected non neuronal cell model) that could benefit treatment.

Call for proposal

Data not available

Coordinator

UNIVERSITE JOSEPH FOURIER - GRENOBLE 1
Address
Domaine De La Merci - Faculté De Médecine
38706 La Tronche
France

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Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Domaine De La Merci - Faculté De Médecine
38706 La Tronche

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue De La Ferollerie, 3B
45071 Orleans

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UNIVERSIDAD DE ZARAGOZA
Spain
Address
Miguel Servet, 177
50013 Zaragoza

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UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Piazzale Aldo Moro, 5
00185 Roma

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UNIVERSITÀ DEGLI STUDI - L'AQUILA
Italy
Address
Via Vetoio
67010 Coppito-l'aquila

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