Role for the endogenous cannabinoid system in ethanol and nicotine addiction: implications for the treatment of drug abuse (CANNABINOID ALCOHOLISM)

Informations projet

CANNABINOID ALCOHOLI

N° de convention de subvention: QLG4-CT-2001-01691

Projet clôturé

Date de début 1 Janvier 2002

Date de fin 31 Decembre 2004

Financé au titre de

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Coût total € 585 936,00

Contribution de l’UE € 459 772,00

Coordonné par

UNIVERSIDAD COMPLUTENSE DE MADRID
Spain

Objectif

This proposal is aimed to explore the role of the endogenous cannabinoid system (ECS) on the development of ethanol and nicotine tolerance, rewarding effects and physical dependence. The studies will be done in normal mice and rats as well as in CB1 knockout mice and Sardinian Alcohol Proffering rats. We will characterize the changes induced by acute or chronic ethanol/nicotine administration on the ECS, (Enzymes for synthesis and metabolism of endocannabinoids and cannabinoid CB1 receptors and its transudation systems), as well as the activity of drugs acting at the ECS in drug ethanol/nicotine self administration and withdrawal. The final goal is to investigate the utility of drugs targeting the ECS for the treatment of alcoholism and tobacco addiction.

Champ scientifique

• medical and health sciences › health sciences › substance abuse
• natural sciences › chemical sciences › organic chemistry › alcohols
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Thème(s)

• 1.1.1.-10. - Public health and health services research

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

UNIVERSIDAD COMPLUTENSE DE MADRID

• Contribution de l’UE: Aucune donnée
• Adresse: Campus de Somosaguas, Edificio Lateral II ; 28223 MADRID ; Espagne
• Coût total: Aucune donnée

Participants (4)

CENTRO CONSORTILE RICERCHE NEUROPSICOFARMACOLOGICHE A.R.L.

Italie

• Contribution de l’UE: Aucune donnée
• Adresse: Z.I. di Macchiareddu, Sesta Strada Ovest ; 09010 BUGGERRU
• Coût total: Aucune donnée

UNIVERSITAT POMPEU FABRA

Espagne

• Contribution de l’UE: Aucune donnée
• Adresse: C/ Dr. Aiguader 80 ; 08003 BARCELONA
• Coût total: Aucune donnée

UNIVERSITE LIBRE DE BRUXELLES

Belgique

• Contribution de l’UE: Aucune donnée
• Adresse: 808,Route de Lennik 808 Campus Erasme - Building C ; 1070 BRUXELLES
• Coût total: Aucune donnée

UNIVERSITY OF CAGLIARI

Italie

• Contribution de l’UE: Aucune donnée
• Adresse: Citadella Universitaria di Monserrato ; 09042 MONSERRATO
• Coût total: Aucune donnée