Involvement of PKCgamma in long-lasting hyperalgesia induced by optiate analgesics

Objective

Using both behavioural and cellular approaches on PKCgamma knockout/wild-type mice, this project will evaluate the contribution of this enzyme in the delayed effects of fentanyl (hyperalgesia, tolerance, withdrawal, psychoaffective effects and cognitive deficits), an opiate analgesic widely used in human surgery.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Funding Scheme

Coordinator

Participants (1)