Safety evaluation of horizontal gene transfer from genetically modified organisms to the microflora of the food chain and human gut

Objective

This project addresses the assessment of possible gene transfer from genetically modified organisms (GMO-plants and-micro organisms) to the micro flora of the food chain. For appropriate implementation of national and EU regulations, there is still a lack of knowledge concerning the transfer of non-équivalent DNA. The risk of horizontal gene transfer will be addressed based on the outcome of the exploitation of several donor recipient combinations in different environments. Therefore we will use food models, models that mimic the ecological habitat in the rumen and human gastro-intestinal tract. In this coordinated project we will study all parameters involved in horizontal gene transfer. All data resulting from the different tests in the variety of model systems will yield validates model systems for studying HGT.

Fields of science

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › genetics › DNA

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-1. - Key action Food, Nutrition and Health

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NETHERLANDS ORGANISATION FOR APPLIED SCIENTIFIC RESEARCH - TNO

Address

48,utrechtseweg 48
3700 AJ Zeist
Netherlands

Participants (4)

DANISH VETERINARY AND FOOD ADMINISTRATION

Denmark

Address

Moerkhoej Bygade 19
2860 Soeborg

Institut National de la Recherche Agronomique (INRA)

France

Address

147 Rue De L'université
75341 Paris

UNIVERSITAET HOHENHEIM

Germany

Address

Schloss 1
70599 Stuttgart

UNIVERSITY OF VIENNA

Austria

Address

Dr Karl Lueger - Ring 1
1010 Wien