Skip to main content

Heterocyclic amines in cooked foods - role in human health

Objective

Carcinogenic heterocyclic amines (HAs) are formed at ppb level during cooking of meat and fish. Epidemiological studies have shown a correlation between the intake of fried meat and cancer. The carcinogen city of HAs has been shown in mice, rats and non-human primates. The human risk of HA intake is not clarified, but depends on the level of exposure, dietary factors influencing the uptake and biotransformation, and on the capacity of the individual to handle HAs. With a multidisciplinary approach, we will improve our understanding of the health risks. Exposure will be determined by new methods for analysis of HAs in foods and for biomarkers of internal and bioactive dose. Endogenous handling will be studied using cloning techniques; critical human enzymes and polymorphisms/genetic susceptibility in the bioactivation and detoxification of HAs and individual DNA repair capacity will be characterized. Exogenous dietary factors modifying the biological handling will be investigated.
The standardised methods to analyse HAs in heat-treated processed foods in connection with HA data on contents in cooked foods, the data on endogenous factors modifying the health effects of HAs, and data on exogenous (dietary) factors modifying the health effects of HAs, and data on exogenous (dietary) factors modifying the health effects of HAs produced in the project will be useful tools for advancement for the food industry to assure the public about harmless levels of HAs in processed foods, and for health authorities to control the occurrence and permissible amounts of HAs in foods.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LUND UNIVERSITY
Address
Paradisgatan 2
221 00 Lund
Sweden

Participants (9)

DANISH VETERINARY AND FOOD ADMINISTRATION
Denmark
Address
Moerkhoej Bygade 19
2860 Soeborg
GERMAN INSTITUTE OF HUMAN NUTRITION
Germany
Address
Arthur-scheunert-allee 114-116
14558 Bergholz-rehbruecke
GRAZ, UNIVERSITY OF TECHNOLOGY
Austria
Address
Rechbauerstrasse 12
8010 Graz
Institute of Cancer Research (Vienna)
Austria
Address
Borschkegasse 8A
1090 Wien
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Staudinger Weg 7
55099 Mainz
NORWEGIAN INSTITUTE OF PUBLIC HEALTH
Norway
Address
75,Geitmyrsveien 75 Torshov
0403 Oslo
UMWELTMEDIZIN HAMBURG E.V.
Germany
Address
Vogt-kölln-strasse 30
22527 Hamburg
UNIVERSITAT DE BARCELONA
Spain
Address
647,Marti I Franques, 1-11
08028 Barcelona
UNIVERSITY OF VIENNA
Austria
Address
Dr Karl Lueger - Ring 1
1010 Wien