Objective Carcinogenic heterocyclic amines (HAs) are formed at ppb level during cooking of meat and fish. Epidemiological studies have shown a correlation between the intake of fried meat and cancer. The carcinogen city of HAs has been shown in mice, rats and non-human primates. The human risk of HA intake is not clarified, but depends on the level of exposure, dietary factors influencing the uptake and biotransformation, and on the capacity of the individual to handle HAs. With a multidisciplinary approach, we will improve our understanding of the health risks. Exposure will be determined by new methods for analysis of HAs in foods and for biomarkers of internal and bioactive dose. Endogenous handling will be studied using cloning techniques; critical human enzymes and polymorphisms/genetic susceptibility in the bioactivation and detoxification of HAs and individual DNA repair capacity will be characterized. Exogenous dietary factors modifying the biological handling will be investigated.The standardised methods to analyse HAs in heat-treated processed foods in connection with HA data on contents in cooked foods, the data on endogenous factors modifying the health effects of HAs, and data on exogenous (dietary) factors modifying the health effects of HAs, and data on exogenous (dietary) factors modifying the health effects of HAs produced in the project will be useful tools for advancement for the food industry to assure the public about harmless levels of HAs in processed foods, and for health authorities to control the occurrence and permissible amounts of HAs in foods. Fields of science natural sciencesbiological scienceszoologymammalogyprimatologymedical and health sciencesclinical medicineoncologynatural scienceschemical sciencesorganic chemistryheterocyclic compoundsnatural scienceschemical sciencesorganic chemistryaminesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-1. - Key action Food, Nutrition and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator LUND UNIVERSITY Address Paradisgatan 2 221 00 Lund Sweden See on map EU contribution € 0,00 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all DANISH VETERINARY AND FOOD ADMINISTRATION Denmark EU contribution € 0,00 Address Moerkhoej bygade 19 2860 Soeborg See on map GERMAN INSTITUTE OF HUMAN NUTRITION Germany EU contribution € 0,00 Address Arthur-scheunert-allee 114-116 14558 Bergholz-rehbruecke See on map GRAZ, UNIVERSITY OF TECHNOLOGY Austria EU contribution € 0,00 Address Rechbauerstrasse 12 8010 Graz See on map Institute of Cancer Research (Vienna) Austria EU contribution € 0,00 Address Borschkegasse 8a 1090 Wien See on map JOHANNES GUTENBERG UNIVERSITAET MAINZ Germany EU contribution € 0,00 Address Staudinger weg 7 55099 Mainz See on map NORWEGIAN INSTITUTE OF PUBLIC HEALTH Norway EU contribution € 0,00 Address 75,geitmyrsveien 75 torshov 0403 Oslo See on map UMWELTMEDIZIN HAMBURG E.V. Germany EU contribution € 0,00 Address Vogt-kölln-strasse 30 22527 Hamburg See on map UNIVERSITAT DE BARCELONA Spain EU contribution € 0,00 Address 647,marti i franques, 1-11 08028 Barcelona See on map UNIVERSITY OF VIENNA Austria EU contribution € 0,00 Address Dr karl lueger - ring 1 1010 Wien See on map
