Objective
Carcinogenic heterocyclic amines (HAs) are formed at ppb level during cooking of meat and fish. Epidemiological studies have shown a correlation between the intake of fried meat and cancer. The carcinogen city of HAs has been shown in mice, rats and non-human primates. The human risk of HA intake is not clarified, but depends on the level of exposure, dietary factors influencing the uptake and biotransformation, and on the capacity of the individual to handle HAs. With a multidisciplinary approach, we will improve our understanding of the health risks. Exposure will be determined by new methods for analysis of HAs in foods and for biomarkers of internal and bioactive dose. Endogenous handling will be studied using cloning techniques; critical human enzymes and polymorphisms/genetic susceptibility in the bioactivation and detoxification of HAs and individual DNA repair capacity will be characterized. Exogenous dietary factors modifying the biological handling will be investigated.
The standardised methods to analyse HAs in heat-treated processed foods in connection with HA data on contents in cooked foods, the data on endogenous factors modifying the health effects of HAs, and data on exogenous (dietary) factors modifying the health effects of HAs, and data on exogenous (dietary) factors modifying the health effects of HAs produced in the project will be useful tools for advancement for the food industry to assure the public about harmless levels of HAs in processed foods, and for health authorities to control the occurrence and permissible amounts of HAs in foods.
Fields of science (EuroSciVoc)
- natural sciences biological sciences zoology mammalogy primatology
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
221 00 LUND
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.