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Content archived on 2024-05-15

Evaluation of the inactivation / removal effect of the gelatin manufacturing process on tse infectivity

Objective

For the manufacture of bone gelatine a downscaled Pilot model has been developed and tested to reflect as close as possible the industrial processes and to represent the typical manufacturing conditions. Spiking crushed fresh bone with 30 I V infected mouse brain (BSE agent) and 263 K infected hamster brain (scrape agent) and processing these materials through the downscaled model to produce gelatin. Using the processed material from the whole process to determine the residual infectivity of gelatine and declaim-phosphate by bioassay. Evaluating separately the inactivation capacity on individual process steps of the finishing unit operations by spiking the industrial starting material and processing this material through these steps and measuring the remaining infectivity. In total 17 samples are prepared and submitted to bioassay. All samples are additionally tested by immunoblotting.

Fields of science (EuroSciVoc)

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Topic(s)

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Call for proposal

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

DEM - Demonstration contracts

Coordinator

DELFT GELATIN B.V.
EU contribution
No data
Address
Rotterdamseweg 270
2600 AA DELFT
Netherlands

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (2)

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