Objective Milk protein peptides can inhibit angiotensin-I-converting enzyme (ACE) Drugs, which inhibit ACE, are in widespread use in cardiovascular medicine. Little or no information is available on the physiological efficacy in man of ingesting natural milk protein peptides/hydrolysis's, which inhibit ACE in vitro. Therefore, it is proposed to address this European-wide functional food ingredient problem/opportunity. The proposal objectives are to perform a detailed physiological, physicochemical, immunochemical and catechetical characterisation, in addition to a consumer assessment of these naturally derived inhibitors of ACE. Milk proteins will be hydrolysed using food-grade proteases. Clinical/bio availability trials will be performed in human volunteers. Immunochemical studies will use serum samples from humans fed ACE inhibitory hydrolysis. Catechetical studies will use human cell culture systems. Consumer awareness will be assessed on a global basis. The outcome of this proposal should lead to the development of clinically validated health claims in respect to the physiological efficiency and safety of ingesting milk protein-derived inhibitors of ACE. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-1. - Key action Food, Nutrition and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF LIMERICK Address Plassey technological park 61 Limerick Ireland See on map EU contribution € 0,00 Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all FEDERAL RESEARCH CENTRE FOR NUTRITION AND FOOD Germany EU contribution € 0,00 Address Hermann weigmann straße 1 24103 Kiel See on map GLANBIA INGREDIENTS (BALLYRAGGET) LTD Ireland EU contribution € 0,00 Address Ballyragget Co. kilkenny See on map UNIVERSITY OF DUNDEE United Kingdom EU contribution € 0,00 Address Ninewells hospital and medical school DD1 9SY Dundee See on map
