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Probiotic strains with designed health properties

Objective

The Lactic Acid Bacteria (LAB) is well known for their extensive use in the preparation of fermented food products. In addition, the potential health benefit they may exert in humans has been intensively investigated during the last century. However, the mechanisms underlying the health promoting traits attributed to LAB, especially lactobacilli, remain vastly unknown which has impaired the rational design of robotic screening methods with accurate predictive value. As the probioticarea corresponds to a rapidly expanding market, the DEPROHEALTH project first aims at establishing a correlation between inviter tests and mouse models mimicking important human intestinal disorders such as Inflammatory Bowel Disease, Helicobacter pylori and Rotavirus infections. As these diseases correspond to major public health problems, second generation probioticstrains with enhanced prophylactic or therapeutic properties will also be designed during the project. These designed strains and the isogonics parental ones will be used to unravel mechanisms involved in the immunomodulation capacity of specific Lactobacillus strains.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT PASTEUR DE LILLE
Address
1,Rue Du Professeur Calmette 1
59019 Lille
France

Participants (8)

BARTS & THE LONDON NHS TRUST
United Kingdom
Address
West Smithfield
EC1A 7BE London
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
S/n,poligono De La Coma S/n
46980 Campamento/paterna
FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW
Belgium
Address
35,Ledeganckstraat 35
9000 Gent
RHODIA FOOD SAS
France
Address
Quai Paul-doumer 25
92408 Courbevoie
UNIVERSITAT DE VALENCIA
Spain
Address
Avda. Blasco Ibaçez 17
46071 Valencia
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Address
Croix Du Sud 5
1348 Louvain-la-neuve
UNIVERSITY OF NEW SOUTH WALES
Australia
Address

2052 University Of New South
UNIVERSITÀ DEGLI STUDI DI SIENA
Italy
Address
Viale Bracci Policlinico Dellle Scotte
53100 Siena