Probiotic strains with designed health properties

Objective

The Lactic Acid Bacteria (LAB) is well known for their extensive use in the preparation of fermented food products. In addition, the potential health benefit they may exert in humans has been intensively investigated during the last century. However, the mechanisms underlying the health promoting traits attributed to LAB, especially lactobacilli, remain vastly unknown which has impaired the rational design of robotic screening methods with accurate predictive value. As the probioticarea corresponds to a rapidly expanding market, the DEPROHEALTH project first aims at establishing a correlation between inviter tests and mouse models mimicking important human intestinal disorders such as Inflammatory Bowel Disease, Helicobacter pylori and Rotavirus infections. As these diseases correspond to major public health problems, second generation probioticstrains with enhanced prophylactic or therapeutic properties will also be designed during the project. These designed strains and the isogonics parental ones will be used to unravel mechanisms involved in the immunomodulation capacity of specific Lactobacillus strains.

Fields of science

• medical and health sciences › health sciences › public health
• natural sciences › chemical sciences › organic chemistry › organic acids
• natural sciences › biological sciences › microbiology › bacteriology
• medical and health sciences › clinical medicine › gastroenterology › inflammatory bowel disease

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-1. - Key action Food, Nutrition and Health

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT PASTEUR DE LILLE

Address

1,rue Du Professeur Calmette 1
59019 Lille
France

Participants (8)

BARTS & THE LONDON NHS TRUST

United Kingdom

Address

West Smithfield
EC1A 7BE London

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

S/n,poligono De La Coma S/n
46980 Campamento/paterna

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW

Belgium

Address

35,ledeganckstraat 35
9000 Gent

RHODIA FOOD SAS

France

Address

Quai Paul-doumer 25
92408 Courbevoie

UNIVERSITAT DE VALENCIA

Spain

Address

Avda. Blasco Ibaçez 17
46071 Valencia

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

Address

Croix Du Sud 5
1348 Louvain-la-neuve

UNIVERSITY OF NEW SOUTH WALES

Australia

Address

2052 University Of New South

UNIVERSITÀ DEGLI STUDI DI SIENA

Italy

Address

Viale Bracci Policlinico Dellle Scotte
53100 Siena