Diet is a major factor in the development of obesity, but its interaction with susceptible genotype is poorly understood. We will assess the prevalence of high fat consumers (HFC) and phenotype groups that appear to be resistant (DIO-R) or susceptible (DIO-S) to diet induced obesity (DIO). DNA banks from Huffs who are lean or obese and from obese children who consume a HF or LF diet will be screened using candidate genes. A rat model of DIO will be investigated to identify diagnostic biomarkers of DIO-R or DIO-S, and to define the mechanisms involved in defence of obesity. We will also study the influence of foetal and early life nutrition on relevant phenotypes. We will develop a web site to provide accessible information on diet, energetic and genetic predisposition to obesity to a lay audience, in particular obese children and their families.
Funding SchemeCSC - Cost-sharing contracts
040 01 Kosice
CM19 5AD Harlow
LS2 9JT Leeds