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Dietary and genetic influences on susceptibility or resistance to weight gain on a high fat diet

Objective

Diet is a major factor in the development of obesity, but its interaction with susceptible genotype is poorly understood. We will assess the prevalence of high fat consumers (HFC) and phenotype groups that appear to be resistant (DIO-R) or susceptible (DIO-S) to diet induced obesity (DIO). DNA banks from Huffs who are lean or obese and from obese children who consume a HF or LF diet will be screened using candidate genes. A rat model of DIO will be investigated to identify diagnostic biomarkers of DIO-R or DIO-S, and to define the mechanisms involved in defence of obesity. We will also study the influence of foetal and early life nutrition on relevant phenotypes. We will develop a web site to provide accessible information on diet, energetic and genetic predisposition to obesity to a lay audience, in particular obese children and their families.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ROWETT RESEARCH INSTITUTE
Address
Greenburn Road
AB21 9SB Aberdeen
United Kingdom

Participants (5)

INSTITUTE OF ANIMAL PHYSIOLOGY - SLOVAK ACADEMY OF SCIENCES
Slovakia
Address
Soltesovej 4
040 01 Kosice
PHILIPPS UNIVERSITY MARBURG
Germany
Address
Schützenstrasse 49
35033 Marburg
SMITHKLINE BEECHAM PLC
United Kingdom
Address
New Frontiers Science Park North
CM19 5AD Harlow
UNIVERSITE HENRI POINCARE NANCY 1
France
Address
Rue Lionnois 38
54000 Nancy
UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
LS2 9JT Leeds