Objective
Coeliac disease (CD) is caused by intolerance to gluten, a common food protein. The disease affects approximately one million Europeans. There is strong evidence that CD is the result of aberrant T cell responses to gluten peptides bound to the disease predisposing HLA-DQ molecules. Recently, we have identified several such peptides. Moreover, T cell recognition of many of these peptides is dependant onthem being enzymatic ally modified in a way that promotes their binding to HLA-DQ.These results provide a rationale for the development of CD. We now propose to:
a) To determine the relative importance of the identified peptides.
b) To demonstrate an in vivo effect of these peptides.
c) To investigate the feasibility of therapeutic intervention.
d) To develop reliable and easy to handle test systems for the detection of toxic gluten peptides in food products.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
0027 OSLO
Norway
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