The EU health food market requires new products that can be used as high quality health food supplements (HFS). Many rural areas, esp. in the Mediterranean, have locally use traditional foods with potential positive effects on health and on ageing-related pathologies that now are only known by elderly people. The Consortium intends to study this local knowledge ethno botanically and contribute to the development of new HFS. We plan to evaluate >150 species of food plants in a variety of primary in vitro assays (incl.CRE for memory formation, PPAR mediated transcriptional activity for diabetes type II, a series of 4 cell-based antioxidant assays, inhibition of ecosanoid generation). Active samples will then be studied in mechanistic in vitro/in viva models focusing on the CNS and the cardiovascular system (CVS), e.g.: free radical generation, membrane fluidity, ant oxidative enzymes (CNS); vasorelaxant NO, vascular endothelial function (CVS).
Funding SchemeCSC - Cost-sharing contracts
31 007 Krakow
60439 Frankfurt Am-main