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Mechanisms of ochratoxin a induced carcinogenicity as a basis for an improved risk assessment

Objective

Ochratoxin A is a mycotoxin which contaminates a variety of human food. In experimental animals, ochratoxin A is nephrotoxic and induces tumors, in the kidney, but also in other organs of rodents. In humans, exposure to high levels of ochratoxin An in diet has been linked with chronic renal disease (Balkan endemic nephropathy, interstitial nephritis) and an increased incidence of urinary tract tumours. The proposal includes novel approaches to study mechanisms of ochratoxin A tumorigenicity to kidney and combines studies in vivo and in relevant in vitro models to investigate the occurrence and nature of damage to DNA and other macromolecules induced by ochratoxin A and its metabolites. These studies include sophisticated analytical chemistry and applications of molecular biology to a toxicological problem. After completion, an improved understanding of mechanisms resulting in DNA-damage by ochratoxin A will be obtained.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF WUERZBURG
Address
Versbacher Strasse 9
97078 Wuerzburg
Germany

Participants (6)

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Prince Consort Road, Royal School Of Mines Buildi
SW7 2BP London
INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE
France
Address
Avenue De L'agrobiopole
31326 Aureville
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma
NESTEC S.A.
Switzerland
Address
Vers-chez-les-blanc
1000 Lausanne
UNIVERSITY OF LAUSANE
Switzerland
Address
7,Rue Du Bugnon 7
1005 Lausanne
UNIVERSITÀ DEGLI STUDI DELLA TUSCIA
Italy
Address
Via S. Camillo De Lellis
01100 Viterbo