Objective
Ochratoxin A is a mycotoxin which contaminates a variety of human food. In experimental animals, ochratoxin A is nephrotoxic and induces tumors, in the kidney, but also in other organs of rodents. In humans, exposure to high levels of ochratoxin An in diet has been linked with chronic renal disease (Balkan endemic nephropathy, interstitial nephritis) and an increased incidence of urinary tract tumours. The proposal includes novel approaches to study mechanisms of ochratoxin A tumorigenicity to kidney and combines studies in vivo and in relevant in vitro models to investigate the occurrence and nature of damage to DNA and other macromolecules induced by ochratoxin A and its metabolites. These studies include sophisticated analytical chemistry and applications of molecular biology to a toxicological problem. After completion, an improved understanding of mechanisms resulting in DNA-damage by ochratoxin A will be obtained.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences analytical chemistry
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine nephrology
- medical and health sciences health sciences nutrition
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
97078 WUERZBURG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.