Objective
Ochratoxin A is a mycotoxin which contaminates a variety of human food. In experimental animals, ochratoxin A is nephrotoxic and induces tumors, in the kidney, but also in other organs of rodents. In humans, exposure to high levels of ochratoxin An in diet has been linked with chronic renal disease (Balkan endemic nephropathy, interstitial nephritis) and an increased incidence of urinary tract tumours. The proposal includes novel approaches to study mechanisms of ochratoxin A tumorigenicity to kidney and combines studies in vivo and in relevant in vitro models to investigate the occurrence and nature of damage to DNA and other macromolecules induced by ochratoxin A and its metabolites. These studies include sophisticated analytical chemistry and applications of molecular biology to a toxicological problem. After completion, an improved understanding of mechanisms resulting in DNA-damage by ochratoxin A will be obtained.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural scienceschemical sciencesanalytical chemistry
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesclinical medicinenephrology
- medical and health scienceshealth sciencesnutrition
- natural sciencesbiological sciencesmolecular biology
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
97078 WUERZBURG
Germany