Skip to main content

Generic coronavirus vaccine vectors for protection of farm animals against mucosal infections

Objective

The proposal addresses the welfare and economic value of the 200 million swine and 4 000 million domestic fowl of the European Union bhy the development of attenuated avian and porcine coronaviruses as generic, multivalent and genetically tagged vector vaccines. Discoveries will also permit rational attenuation of coronaviruses, providing new strategies for vaccine development. The approach of targeted recombination has been proven. The major tool is a set of defective coronavirus RNAs containing genes of choice for recombination with attenuated helper coronavirus to produce desired recombinants, including prototype vaccines that are: genetically tagged; rationally attenuated and unable to revert; express genes for protective immunity, including those of porcine circovirus. The role of the latter in the poorly understood post-weaning multi systemic wasting syndrome of pigs, and the induction and basis of protective immunity to it, is part of this proposal.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Institute for Animal Health
Address
Compton Laboratory Compton
RG16 0NN Newbury
United Kingdom

Participants (3)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Calle Serrano 117
Madrid
FORT DODGE VETERINARIA S.A.
Spain
Address
S/n,carretera Camprodon S/n Km13 Finca "La Riba"
17813 Vall De Bianya
WISE & MUNRO LEARNING RESEARCH
Netherlands
Address
8,Azaleastraat 85
2565 CD Den Haag