Multi-component salmonella livev vaccines: optimising molecular, cellular and immunological parameters to enhance vaccine safety and immunogenicity.

Objective

This proposal comprises two specific research thrusts. First, to support the development of fibrin micro beads (FMB) to enhance soft tissue repair and provide new cell delivery vehicles. In this thrust, most of our efforts will be focused on evaluating the use of plasma derived FMB for tissue engineering. For both mechanistic insights as well as potentially improved product safety, we will also evaluate r-FMB using recombinant fibrinogen derived from sheep milk, licensed from PPL to Smith & Nephew, for exploitation in tissue repair. In the second thrust the consortium will address the basic biochemistry of fibrinogen and related clotting factors (thrombin and factor XIII) in wound healing, supported by preclinical studies to assess in vivo activity. Comparisons with recombinant analogues will be made.

Fields of science

• natural sciences › biological sciences › biochemistry
• medical and health sciences › medical biotechnology › tissue engineering
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF ERLANGEN-NUREMBERG

Address

Wasserturmstraße 3
91054 Erlangen
Germany

Participants (3)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

Campus Cantoblanco, Universidad Autonoma
28049 Madrid

GBF - NATIONAL CENTRE FOR BIOTECHNOLOGY

Germany

Address

Mascheroder Weg 1
38124 Braunschweig

Institute for Animal Health

United Kingdom

Address

Compton Laboratory Compton
RG16 0NN Newbury