The overall objective of this cluster is to contribute to the development of preventive and therapeutic vaccines against hepatitis C virus (HCV) infection. For this objective an in depth understanding of protective antiviral immune responses is essential by acquiring knowledge on mechanisms associated with HCV replication, assembly and fundamental knowledge on HCV specific immune responses in natural infections. A key element in the development of a vaccine is the choice of a delivery system capable to induce a humoral and/or a cellular-mediated protective immune response. The networks in this cluster proposal have strong, worldwide recognized expertise and have all parameters to monitor the planned analysis from fundamental in vitro studies to the evaluation of vaccine candidates in non-human primates. The basic strength of the Cluster is to re-unite expertise and unique systems that will allow a solid basis for the definition of clinical trials.
Funding SchemeCSC - Cost-sharing contracts
79106 Freiburg (In Breisgau)
2288 GJ Rijswijk Zh
171 77 Stockholm
OX3 9DU Oxford/headington