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A new vaccine strategy against serogroup b meningococcal infection: from antigen discovery to clinical trials

Objective

The aim of this proposal is to design a new vaccine strategy to prevent endemic sero- group B meningococcal infections. Previous strategies using outer membrane vesicles(OMV) purified from epidemic strains have been successful but remained limited to epidemic be- cause the immune response was restricted to strains homologous to that used to prepare the vaccine. In this proposal, we will develop an OMV vaccine using a genetically modified serogroup B strain to express high amount of an antigen that induces bactericidal antibodies against a wide range of MenB strains. This new vaccine wills
(i)benefit from the proven technology of using an OMV vaccine that presents the native antigen in outer membrane, and
(ii)improve that technology by including antigens that are efficient against a wide range of strains. This proposal encompass two major parts.
(i) The identification of outer membrane component(s)that are suitable for over expression in the vaccine strain
(ii)The over expression of successful candidates in the suitable strain. The recombinant bacteria will be used to produce OMVs and the OMV will be tested in human volunteers.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

GLAXOSMITHKLINE BIOLOGICALS SA
Address
Rue De L'institut 89
--- Rixensart
Belgium

Participants (8)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
KAROLINSKA INSTITUTE
Sweden
Address
Solnavagen 1
171 77 Stockholm
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Hofgartenstrasse 8
Muenchen
MICROBIOLOGICAL RESEARCH AUTHORITY
United Kingdom
Address
Porton Down
SP4 0JG Salisbury
NATIONAL BIOLOGICAL STANDARDS BOARD
United Kingdom
Address
Blanche Lane, South Mimms
Potters Bar
NORWEGIAN INSTITUTE OF PUBLIC HEALTH
Norway
Address
75,Geitmyrsveien 75 Torshov
0403 Oslo
THE NATIONAL HOSPITAL UNIVERSITY OF OSLO
Norway
Address
Pilestredet 32
0027 Oslo
WISE & MUNRO LEARNING RESEARCH
Netherlands
Address
8,Azaleastraat 85
2565 CD Den Haag