Objective The aim of this proposal is to design a new vaccine strategy to prevent endemic sero- group B meningococcal infections. Previous strategies using outer membrane vesicles(OMV) purified from epidemic strains have been successful but remained limited to epidemic be- cause the immune response was restricted to strains homologous to that used to prepare the vaccine. In this proposal, we will develop an OMV vaccine using a genetically modified serogroup B strain to express high amount of an antigen that induces bactericidal antibodies against a wide range of MenB strains. This new vaccine wills(i)benefit from the proven technology of using an OMV vaccine that presents the native antigen in outer membrane, and(ii)improve that technology by including antigens that are efficient against a wide range of strains. This proposal encompass two major parts.(i) The identification of outer membrane component(s)that are suitable for over expression in the vaccine strain(ii)The over expression of successful candidates in the suitable strain. The recombinant bacteria will be used to produce OMVs and the OMV will be tested in human volunteers. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator GLAXOSMITHKLINE BIOLOGICALS SA EU contribution No data Address Rue de l'Institut 89 --- RIXENSART Belgium See on map Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue de Tolbiac, 101 75654 PARIS See on map Total cost No data KAROLINSKA INSTITUTE Sweden EU contribution No data Address Solnavagen 1 171 77 STOCKHOLM See on map Total cost No data MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address Hofgartenstrasse 8 MUENCHEN See on map Links Website Opens in new window Total cost No data MICROBIOLOGICAL RESEARCH AUTHORITY United Kingdom EU contribution No data Address Porton Down SP4 0JG SALISBURY See on map Total cost No data NATIONAL BIOLOGICAL STANDARDS BOARD United Kingdom EU contribution No data Address Blanche lane, South Mimms POTTERS BAR See on map Links Website Opens in new window Total cost No data NORWEGIAN INSTITUTE OF PUBLIC HEALTH Norway EU contribution No data Address 75,Geitmyrsveien 75 Torshov 0403 OSLO See on map Total cost No data THE NATIONAL HOSPITAL UNIVERSITY OF OSLO Norway EU contribution No data Address Pilestredet 32 0027 OSLO See on map Total cost No data WISE & MUNRO LEARNING RESEARCH Netherlands EU contribution No data Address 8,Azaleastraat 85 2565 CD DEN HAAG See on map Links Website Opens in new window Total cost No data
