A new vaccine strategy against serogroup b meningococcal infection: from antigen discovery to clinical trials

Objective

The aim of this proposal is to design a new vaccine strategy to prevent endemic sero- group B meningococcal infections. Previous strategies using outer membrane vesicles(OMV) purified from epidemic strains have been successful but remained limited to epidemic be- cause the immune response was restricted to strains homologous to that used to prepare the vaccine. In this proposal, we will develop an OMV vaccine using a genetically modified serogroup B strain to express high amount of an antigen that induces bactericidal antibodies against a wide range of MenB strains. This new vaccine wills
(i)benefit from the proven technology of using an OMV vaccine that presents the native antigen in outer membrane, and
(ii)improve that technology by including antigens that are efficient against a wide range of strains. This proposal encompass two major parts.
(i) The identification of outer membrane component(s)that are suitable for over expression in the vaccine strain
(ii)The over expression of successful candidates in the suitable strain. The recombinant bacteria will be used to produce OMVs and the OMV will be tested in human volunteers.

Fields of science

• natural sciences › biological sciences › microbiology › bacteriology
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

GLAXOSMITHKLINE BIOLOGICALS SA

Address

Rue De L'institut 89
--- Rixensart
Belgium

Participants (8)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Address

Rue De Tolbiac, 101
75654 Paris

KAROLINSKA INSTITUTE

Sweden

Address

Solnavagen 1
171 77 Stockholm

MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

Address

Hofgartenstrasse 8
Muenchen

Links

MICROBIOLOGICAL RESEARCH AUTHORITY

United Kingdom

Address

Porton Down
SP4 0JG Salisbury

NATIONAL BIOLOGICAL STANDARDS BOARD

United Kingdom

Address

Blanche Lane, South Mimms
Potters Bar

Links

NORWEGIAN INSTITUTE OF PUBLIC HEALTH

Norway

Address

75,geitmyrsveien 75 Torshov
0403 Oslo

THE NATIONAL HOSPITAL UNIVERSITY OF OSLO

Norway

Address

Pilestredet 32
0027 Oslo

WISE & MUNRO LEARNING RESEARCH

Netherlands

Address

8,azaleastraat 85
2565 CD Den Haag

Links