Objective The objectives of Neavac-Ec are :1) to increase knowledge of immunological factors which, in early infancy, lead to a high susceptibility to infectious diseases and to relatively weak vaccine-induced responses;2) to define optimal vaccine design and new immunization strategies for the rapid induction, in early life, of protective vaccine responses and long lasting immunological memory; 3)to identify and standardize suitable evaluation procedures (in vitro/in vivo, animal models/human, Dendrite Cell (DC), T and B cells responses) for the initial assessment of future vaccines/ delivery systems/ adjuvant considered for use in early life. A Tran disease approach has been adopted, focusing on(I) analysis of the Maturation of early life immune responses in humans and animal models and(ii) optimisation of vaccines against 3 selected important early life pathogens (S.pneumoniae B. peruses, Respiratory Syncytial Virus). This should contribute to establishing the generic principles of early life immunization and promote their concrete application to the industrial development of vaccines of high priority for both human and veterinary diseases.The overall achievements of Neovac have been more extensive that what could be expected. Substantial progress has been made towards a better understanding of the basic aspects of immune responses to vaccines in the neonatal period, particularly at the level of dendritic cells, opening the way to the design of appropriate vaccine formulations. In addition, results of considerable practical importance were obtained:- A new vaccinations strategy has been defined that may open the way to neonatal prevention of early life Pertussis.- Innovative immunisation approaches that are based on novel adjuvants, new formulations or new carriers were shown to be effective in models of early life diseases caused by RSV or Pneumococcus.These discoveries have a real potential to influence future vaccination programmes and to have an impact on disease burden resulting from these infections, not only in Europe but as well at global level. Fields of science medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator AVENTIS PASTEUR SA EU contribution No data Address 1541,Avenue Marcel Mérieux 1541 69280 MARCY-L'ETOILE France See on map Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all CHIRON S.R.L. Italy EU contribution No data Address VIA FIORENTINA 1 53100 SIENA See on map Links Website Opens in new window Total cost No data IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE United Kingdom EU contribution No data Address South Kensington Campus LONDON See on map Total cost No data INSTITUT PASTEUR France EU contribution No data Address Rue du Docteur Roux 25 75724 PARIS See on map Total cost No data INSTITUT PASTEUR DE LILLE France EU contribution No data Address Rue du Professeur Calmette 1 INSERM U168 59019 Lille See on map Total cost No data NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland EU contribution No data Address Belfield DUBLIN See on map Total cost No data PIERRE FABRE MEDICAMENT S.A. France EU contribution No data Address Avenue Napoléon III , 5 Le Puy Saint Martin 74164 SAINT JULIEN-EN-GENEVOIS See on map Total cost No data THE SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES Sweden EU contribution No data Address 10,Arrheniusplan 2C 750 07 UPPSALA See on map Total cost No data THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution No data Address Senate House, Abercromby Square L69 3SG LIVERPOOL See on map Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address 30,Guilford Street 30 WC1N 1EH LONDON See on map Total cost No data UNIVERSITY OF GENEVA Switzerland EU contribution No data Address 24,Rue General Dufour 24 1211 GENEVE See on map Total cost No data Universite Libre de Bruxelles Belgium EU contribution No data Address Avenue Franklin Roosevelt 50 BRUXELLES See on map Links Website Opens in new window Total cost No data