Objective
Development of a safe and effective vaccine against human respiratory syncytial virus, and its close bovine relative, remains a high priority. These viruses are the most important cause of severe respiratory infections in very young children and calves. We intend to use recently developed techniques for rescuing negative- stranded RNA viruses from cDNA copies of the entire genome. This approach offers the possibility of using highly developed genetic engineering techniques for introducing desired mutations in the viral genome. Minigenome amplication and alternative assays will be used for rapid screening of promising mutations that may be then transferred to full-length cDNA clones for virus rescue. Mutant viruses will be tested in cell and organ cultures for growth and induction of key regulatory molecules. Viruses with interesting phenotypes will be tested in animal models, including calves as a natural host of bovine respiratory syncytial virus.
Fields of science (EuroSciVoc)
- medical and health sciences health sciences infectious diseases RNA viruses
- natural sciences biological sciences microbiology virology
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences genetics genomes viral genomes
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28220 MAJADAHONDA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.