Recently a novel porcine circovirus (PCV2) has been identified and associated with a new wasting disease syndrome in pigs (PMWS) worldwide. Reproduction of PMWS in gnotobiotic and colostrums-deprived pigs with PCV2 has been achieved and vertical transmission of PCV2 has been reported. PCV2 nucleic acid has been demonstrated in cattle and sheep and antibody to PCV demonstrated in humans and cattle. PCV2 is an emerging pathogen worldwide with potential for exploitation as a target for combination of in vitro and in vivo experimental infections and epidemiological surveys within EU member states and elsewhere. In vitro and in vivo analysis of the immunopathology of PCV2 infections of pigs will be carried out, as will a study of the serological and genomic relations ships between PCV2 isolates from differing disease syndromes and different geographical locations. This information’s will be applied to the preparation and preliminary testing of second and third generation candidate vaccines in an exp0 challenge model.
Funding SchemeCSC - Cost-sharing contracts
SKS 7N4L3 Saskatoon