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Novel circovirus infections of pigs: a target for vaccination. porcine circoviruses

Objective

Recently a novel porcine circovirus (PCV2) has been identified and associated with a new wasting disease syndrome in pigs (PMWS) worldwide. Reproduction of PMWS in gnotobiotic and colostrums-deprived pigs with PCV2 has been achieved and vertical transmission of PCV2 has been reported. PCV2 nucleic acid has been demonstrated in cattle and sheep and antibody to PCV demonstrated in humans and cattle. PCV2 is an emerging pathogen worldwide with potential for exploitation as a target for combination of in vitro and in vivo experimental infections and epidemiological surveys within EU member states and elsewhere. In vitro and in vivo analysis of the immunopathology of PCV2 infections of pigs will be carried out, as will a study of the serological and genomic relations ships between PCV2 isolates from differing disease syndromes and different geographical locations. This information’s will be applied to the preparation and preliminary testing of second and third generation candidate vaccines in an exp0 challenge model.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE QUEEN'S UNIVERSITY OF BELFAST
Address
Stoney Road , Stormont
BT4 3SD Belfast
United Kingdom

Participants (6)

DANISH INSTITUTE FOR FOOD AND VETERINARY RESEARCH
Denmark
Address
Lindholm
4771 Kalvehave
GENT UNIVERSITY
Belgium
Address
Sint Pietersnieuwstraat 25
9000 Gent
INSTITUTE OF VIROLOGY AND IMMUNOPROPHYLAXIS
Switzerland
Address
Sensemattstrasse 293
3147 Mittelhauesern
MERIAL SAS
France
Address
Rue Bourgelat 17
69002 Lyon
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
United States
Address
Kenny Road 1960
43210-1093 Columbus
UNIVERSITY OF SASKATCHEWAN
Canada
Address
Campus Drive 97
SKS 7N4L3 Saskatoon