Objective Vaccine design has mainly been based on a trial and error method without specific knowledge of requirements in terms of antigen composition and presentation, and the quality of immune response needed. In this project, we will use a methodological approach for designing efficacious and safe marker vaccines based on the identification of immuno-protective antigens, we will use efficient and biologically safe delivery systems and establish the quality of immunity required for prevention of disease and virus transmission. Using nucleic acid vaccine technology, parts of viral genome will be screened for novel immuno-protective antigens by expression library immunisation (ELI). Enhancement of the efficacy and bio safety of nucleic acid vaccines will be sought through1) adjuration CpG motifs,2) favouring T cell immunity through antigen - ubiquitin fusion,3) using auto-replicative Sindbis vectors and respectively4) species restricted promoters. Moreover, we will compare the efficacy of nucleic acid delivery with a potentially effective and safe antigen delivery system based on attenuated Orf virus recombinant vectors. Throughout the project, the type of immune responses will be analysed in relation to the quality if immunity that prevents disease and virus transmission, thereby defining correlates of vaccine induced immune protection. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsmedical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS Address Bp 53 22440 Ploufragan France See on map EU contribution € 0,00 Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all CIDC-LELYSTAD, CENTRAAL INSTITUUT DIERZIEKTE CONTROLE LELYSTAD Netherlands EU contribution € 0,00 Address Houtribweg 39 8221 RA Lelystad See on map FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH Germany EU contribution € 0,00 Address Paul ehrlichstr. 28 72076 Tuebingen See on map UNIVERSITY OF GDANSK Poland EU contribution € 0,00 Address 24,kladki 24 80 822 Gdansk See on map
