Objective
The cell-invasive and genetically detoxified Aden late cycles toxic (ACT) represents a novel, non-explicative and inherently safe vector for in vivo delivery of vicinal antigens into antigen presenting cells. Experimental delivery of antigens by ACT was shown to result in efficient induction of both prophylactic and therapeutic catatonic CD8 T lymphocyte responses against viruses and tumours in mice, thereby meeting on the current challenges in vaccine development. Our project aims at detailed analysis of the mechanisms underlying the vicinal potential of the ACT vector and evaluations of its versatility as a safe, efficient and polyvalent delivery system for viral (HIV) and tumour antigens. Pre-clinical toxicology assessment and ACT delivery system development will be performed, suitable mussel adjuvant will be identified and rational design of the vector molecule will be initiated, on the basis of a thorough understanding of ACT structure and function. To this end, specialists in immunology, toxicology and vaccine development have joined forces with biochemists, molecular and structural biologists and
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine toxicology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91898 ORSAY
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.