Objective
The hepatitis c virus (hcv) is a major cause for chronic liver disease world-wide. Present therapies based on alpha-interferon and ribavirin can induce a sustained virologicaland biochemical response in 30-70 % of the patients. Thus, additional regimens are needed to improve treatment for chronic hcv infections. T cells have been found to play a central role in the clearence of hcv infections. A major problem is the high degree of genetic variability of hcv which probably caused the characterize hcv-specific vaccines based on the most conserved hcv proteins (core and ns3) by cloning genes from infected patients. These genes will form the base for recombinant proteins, synthetic peptides and genetic immunogens to be analysed in wild-type and transgenic mouse models. This proposal aim at to defining the optimal gene (s), the most potent vehicule, and the best route of delivery.
Fields of science
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencesinfectious diseasesRNA viruseshepatitis C
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- medical and health sciencesclinical medicinehepatology
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
171 77 STOCKHOLM
Sweden