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Interruption of malaria transmission : vaccine strategies

Objective

Malaria is a major infectious disease in the world with tremendous impact on quality of life. Malaria control is difficult and the available tools are limited. Vaccines will be the only long-term and cost-effective tools to control this ever-growing problem. Malaria is transmitted by sexual stages of Plasmodium falciparum. Sexual stage malaria vaccines aim at an arrest of the transmission and therefore spread or (re)-introduction of malaria in a risk area. The objectives are focussed on production and development of a transmission-blocking (TB)-vaccine. The objectives and expected outcome include
1) production of a TBPfs48/45 peptide vaccine up to the phase of clinical testing
2) identification of novel parasite antigens on gametocyte-infected red blood cells, gametes/kookiness and mosquitoes.
3) improvement of (bio)-assays for TB-immunity by the use of quantitative molecular techniques and development of immune correlates of protection.
4) Application of (new) animal models (marine, non-human primates) to be used in studies on biological function with genetically modified parasites and for pre-screening for human trials.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
22,Geert Grooteplein Zuid 22
6500 HB Nijmegen
Netherlands

Participants (8)

FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE
Netherlands
Address
151,Lange Kleiweg 151
2280 GH Rijswijk Zh
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Campus At Silwood Park, Road A329 (Virginia Water
SW7 2AZ London
LEIDEN UNIVERSITY
Netherlands
Address
72,Rapenburg 70
2311 EZ Leiden
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
UNIVERSIDADE NOVA DE LISBOA
Portugal
Address
Campus De Campolide
1099 085 Lisboa
UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
Glasgow
University of Aberdeen
United Kingdom
Address
2 Tillydrone Avenue
AB9 2TN Aberdeen