Objective Malaria is a major infectious disease in the world with tremendous impact on quality of life. Malaria control is difficult and the available tools are limited. Vaccines will be the only long-term and cost-effective tools to control this ever-growing problem. Malaria is transmitted by sexual stages of Plasmodium falciparum. Sexual stage malaria vaccines aim at an arrest of the transmission and therefore spread or (re)-introduction of malaria in a risk area. The objectives are focussed on production and development of a transmission-blocking (TB)-vaccine. The objectives and expected outcome include1) production of a TBPfs48/45 peptide vaccine up to the phase of clinical testing2) identification of novel parasite antigens on gametocyte-infected red blood cells, gametes/kookiness and mosquitoes.3) improvement of (bio)-assays for TB-immunity by the use of quantitative molecular techniques and development of immune correlates of protection.4) Application of (new) animal models (marine, non-human primates) to be used in studies on biological function with genetically modified parasites and for pre-screening for human trials. Fields of science natural sciencesbiological scienceszoologymammalogyprimatologymedical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological scienceszoologyinvertebrate zoology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator STICHTING KATHOLIEKE UNIVERSITEIT Address 22,geert grooteplein zuid 22 6500 HB Nijmegen Netherlands See on map Links Website Opens in new window EU contribution € 0,00 Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Netherlands EU contribution € 0,00 Address 151,lange kleiweg 151 2280 GH Rijswijk zh See on map IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE GB EU contribution € 0,00 Address Campus at silwood park, road a329 (virginia water SW7 2AZ London See on map LEIDEN UNIVERSITY Netherlands EU contribution € 0,00 Address 72,rapenburg 70 2311 EZ Leiden See on map LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE EU contribution € 0,00 Address See on map THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD GB EU contribution € 0,00 Address University offices, wellington square Oxford See on map Links Website Opens in new window UNIVERSIDADE NOVA DE LISBOA Portugal EU contribution € 0,00 Address Campus de campolide 1099 085 Lisboa See on map UNIVERSITY OF GLASGOW GB EU contribution € 0,00 Address University avenue Glasgow See on map University of Aberdeen GB EU contribution € 0,00 Address 2 tillydrone avenue AB9 2TN Aberdeen See on map
