Objective
To create novel mucosal vaccination approaches efficient bacterial live carrier vaccines will be developed by rational design and genetic engineering. Enteric Perinea sop. will be attenuated by targeted disruption of genes encoding virulence factors. Taking adman- tag of the type III protein secretion apparatus of Perinea, heterogonous model anti- genes (ovalbumin, OVA; haemagglutinin, HA) will be fused to Tran located Perinea Yaps to target the antigens to MHC class I or II antigen processing pathways in host cells. Imp- mane responses and effectors mechanisms induced by these vaccines will be evaluated in a mouse infection model including OVA- and HA-TCR transgenic mice as well as with human cells.
Furthermore, antigens of classical swine fever virus will be used and immune rest- poses will b analysed in a swine model. The combined efforts of a multidisciplinary collaboration between six academic institutes and one European vaccine company with highly complementary expertise will allow the development of a new generation of live carrier vaccines with (see the follow on the original text)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 MUENCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.