European network for vaccine evaluation in primates: combined vector immunisations for aids vaccine development

Objective

Important vaccine against human pathogens, e.g. poliomyelitis virus and hepatitis B virus, could only be developed by trials in non-human primates. BSL 2 or 3 facilities suitable for housing infected non-human primates are scarce in Europe. No single European institute can house sufficient animals to generate statistically reliable results comparing multiple vaccine strategies. Thus, eight European primate facilities will establish a network for preclinical vaccine evaluation in non-human primates. To contribute to AIDS vaccine development and to prove our capacity to conduct highly co-ordinated vaccine trials, we propose to optimise combination of three genetically- based vaccines in a multi-centre experiment. Our concerted approach will optimise scarce European resources, improve our ability to conduct preclinical vaccine trials in relevant challenge models and enhance the global competitiveness of European vaccine developers.

Fields of science

• natural sciences › biological sciences › zoology › mammalogy › primatology
• medical and health sciences › basic medicine › immunology › immunisation
• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › health sciences › infectious diseases › RNA viruses › HIV
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

DEUTSCHES PRIMATENZENTRUM GMBH

Address

4,kellnerweg 4
37077 Göttingen
Germany

Participants (7)

COMMISSARIAT A L'ENERGIE ATOMIQUE

France

Address

Rue De La Federation 31-33
75015 Paris

FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE

Netherlands

Address

Lange Kleiweg 139
2288 GJ Rijswijk Zh

Head of the Unit of Foodborne Zoonoses and Veterinary Epidemiology

Italy

Address

Viale Regina Elena 299
00161 Rome

Links

MICROBIOLOGICAL RESEARCH AUTHORITY

United Kingdom

Address

Porton Down
SP4 0JG Salisbury

NATIONAL BIOLOGICAL STANDARDS BOARD

United Kingdom

Address

Blanche Lane, South Mimms
Potters Bar

Links

PAUL-EHRLICH-INSTITUT, FEDERAL AGENCY FOR SERA AND VACCINES

Germany

Address

Paul-ehrlich-strasse 51-59
63225 Langen

SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL

Sweden

Address

Nobels Vaeg 18
Solna

Links