Objective
The overall objective of the Cluster is to establish a framework for preclinical development of novel tuberculosis vaccine candidates. We aim to identify optimal strategies for generation of vaccine candidates by comparing innovative approaches based on identification of novel protein antigens, characterisation of non-protein antigens that elicit T cell responses in man, and construction of live attenuated strains of mycobacteria. New vaccines will be compared alone or in combination in standardised experimental challenge models to identify candidates superior to the existing BCG vaccine. In parallel, the immunological mechanisms underlying vaccine-induced protection will be characterised in man and in experimental models. This information will be used to develop immunological tests for initial clinical assessment of new vaccines. Integration of these activites, with the participation of the top academic and industrial researchers in Europe (Aventis Pasteur, SmithKline Beecham and the Statens Serum Institut), is essential for completion of the final goal of bringing one or more new vaccines to a stage suitable for clinical trials.
Brief description
The workplan for the Cluster is based on five interactive component
Projects. Project 1 will focus on establishment of a standardised protocol
for preclinical assessment of vaccine candidates in a series of animal challenge models. Protein antigens with known vaccine potential will be used for comparative evaluation of delivery systems based on novel adjuvants, DNA constructs, and attenuated viral vectors. Candidates that perform optimally in naive challenge models in mice and guinea pigs will be taken forward into screening in bovine and primate models. Projects 2 and 3 are directed towards discovery of new vaccine candidates which will subsequently feed into the preclinical screening programme established in Project 1. Participants in Project 2 will use powerful new tools for genetic manipulation of mycobacteria to construct a new generation of live attenuated mycobacterial vaccines. These will include recombinant BCG strains optimised for immunogenicity and safety, as well as M. tuberculosis strains lacking key virulence determinants following random transposon mutagenesis or predictions from bioinformatic and comparative genomic analysis. Project 3 will focus on novel non-protein antigens from mycobacteria that have recently been demonstrated to induce human T cell responses. A key aspect of the Cluster is that each of these strategies can be pursued simultaneously and that the different classes of candidate can be directly compared against each other and in combination. Finally, participants in Project 4 will study the mechanisms underlying the pathological manifestations of tuberculosis and the protective immune responses induced by the different vaccine candidates. This will identify immunological tests suitable for initial assessment of new vaccines in clinical trials.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75724 PARIS
France
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Participants (29)
08193 BELLATERRA
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69007 LYON
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31077 TOULOUSE
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2280 GH RIJSWIJK ZH
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38124 BRAUNSCHWEIG
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8219 PH LELYSTAD
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LONDON
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75654 PARIS
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59019 LILLE
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00149 ROMA
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2300 RC LEIDEN
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10117 BERLIN
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SP4 0JG SALISBURY
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1180 BRUXELLES
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NW7 1AA London
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POTTERS BAR
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1330 RIXENSART
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2300 KOEPENHAGEN
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SOLNA
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OX3 9DU OXFORD/HEADINGTON
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KT15 3NB ADDLESTONE
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BT4 3SD BELFAST
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AL9 7TA WELHAM GREEN,HATFIEID
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50009 ZARAGOZA
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4031 BASEL
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91058 ERLANGEN
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8028 ZURICH
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GU2 5XH Guildford
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