Establishment of novel targets for risk assessment and monitoring of xenogeneic infections in the course of animal to human transplantation

Objective

This proposal is aiming at a certain number of issues including European Public Health, ethics and economy. Particularly, specifically designed strategies for patient surveillance in order to detect and control putative xenozoonoticinfections shall be developed. Those include PRC based techniques (ultrasensitivereal-time PRC) and specific antibody detection tools (natural virus proteins and recombinant proteins and peptides for ELISA and Western blot assays) for patient surveillance in order to detect and to control putative xenozoonotic infections shall be developed. At current, established regulatory guidance on animal production for xenotransplantation and the validation of European standards of animal health and welfare and risk assessment of possible transmission of diseases from pig to man in the course of transplantation of porcine tissues and whole organs is missing. Novel detection essays will be a prerequisite for defining such guidelines on a European level.

Programme(s)

FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

1.1.1.-2. - Key action Control of Infectious Diseases

Funding Scheme

EAW - Exploratory awards

Coordinator

SCIENCE SERVICE GBR

Address

Grabenstrasse, 5
40213 Duesseldorf
Germany

Participants (1)

ARQTECH LABORATORIES LTD.

Ireland