Development of antimicrobial peptides as novel anti-infective drugs

Objective

The rapid spread of antibiotic resistance requires innovative anti-infective drugs and strategies. The PANAD concept proposes to develop potent antimicrobialpeptides (Amps) to the preclinical stage of investigation. Natural and designed Amps will first be extensively screened in vitro against clinical isolates of pathogens and selected for subsequent testing in animal disease models. Screens will include combinations of Amps with conventional antibiotics. Amps with sufficient potency will be selected for simultaneous knowledge-based design andrandom-mutagenesis to increase performance. Improved Amps will re-enter in vitrotesting to advance the optimisation process. Novel technology for large-scale, cost-effective bio production of Amps will be developed.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › antibiotic resistance

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (5)

AGRICULTURAL UNIVERSITY OF NORWAY

Norway

Address

Kirkeveien 1
1432 Aas

LUND UNIVERSITY

Sweden

Address

Paradisgatan 2
221 00 Lund

NOVOZYMES A/S

Denmark

Address

Krogshoejvej 36
Bagsvaerd

UNIVERSITÀ DEGLI STUDI DI TRIESTE

Italy

Address

Via A. Valerio 10
34127 Trieste

WEIZMANN INSTITUTE OF SCIENCE

Israel

Address

Herzel Street, 2
76100 Rehovot