Objective
The rapid spread of antibiotic resistance requires innovative anti-infective drugs and strategies. The PANAD concept proposes to develop potent antimicrobialpeptides (Amps) to the preclinical stage of investigation. Natural and designed Amps will first be extensively screened in vitro against clinical isolates of pathogens and selected for subsequent testing in animal disease models. Screens will include combinations of Amps with conventional antibiotics. Amps with sufficient potency will be selected for simultaneous knowledge-based design andrandom-mutagenesis to increase performance. Improved Amps will re-enter in vitrotesting to advance the optimisation process. Novel technology for large-scale, cost-effective bio production of Amps will be developed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciencesbiological sciencesbiochemistrybiomolecules
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
You need to log in or register to use this function