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Development of antimicrobial peptides as novel anti-infective drugs

Objective

The rapid spread of antibiotic resistance requires innovative anti-infective drugs and strategies. The PANAD concept proposes to develop potent antimicrobialpeptides (Amps) to the preclinical stage of investigation. Natural and designed Amps will first be extensively screened in vitro against clinical isolates of pathogens and selected for subsequent testing in animal disease models. Screens will include combinations of Amps with conventional antibiotics. Amps with sufficient potency will be selected for simultaneous knowledge-based design andrandom-mutagenesis to increase performance. Improved Amps will re-enter in vitrotesting to advance the optimisation process. Novel technology for large-scale, cost-effective bio production of Amps will be developed.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (5)

AGRICULTURAL UNIVERSITY OF NORWAY
Norway
Address
Kirkeveien 1
1432 Aas
LUND UNIVERSITY
Sweden
Address
Paradisgatan 2
221 00 Lund
NOVOZYMES A/S
Denmark
Address
Krogshoejvej 36
Bagsvaerd
UNIVERSITÀ DEGLI STUDI DI TRIESTE
Italy
Address
Via A. Valerio 10
34127 Trieste
WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzel Street, 2
76100 Rehovot