Objective
We will develop a new class of ant malarial drug that target membrane biogenesis of the erythrocyte stage of Plasmodium falciparum. We have established thatphospholipid synthesis of the parasite, but not the host, is specifically blocked, and that multiresistant malaria is susceptible. To date no resistance has been found. Efficacy and tolerance in mice, dogs, and primates have encouraged drug development for clinical testing. Here we will optimise currently promisingprodrugs and select one candidate for rapid transfer to preclinical studies. We will also assess promising new molecular leads and oral delivery systems. Complementary research will define the molecular mechanisms of drug activity and will more fully characterise parasite serine lipid metabolism. This is unattractive pathway for drug development that is absent in mammalian cells and that offers considerable potential for medium-term pharmacological interventions .
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology mammalogy primatology
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences health sciences infectious diseases malaria
- agricultural sciences animal and dairy science domestic animals
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
34095 MONTPELLIER
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.