Objective
This network intends to coordinate a group of laboratories interested in proteomicanalysis of pathogenic bacteria using advanced HTS technology, and focussing on the comparison of proteases expressed in physiologically relevant conditions .Comparative analysis of proteases expressed by fully sequenced genomes, and parallel transcript analysis with whole-genome DNA micro arrays , are expected to identify sets of proteins which are surface exposed or used by the bacteria to establish infection, or counteract host immunological defences. Such proteins are obvious candidates for vaccine, diagnostics, or antibacterial drugdevelopment.Pilot studies performed on a panel of selected human pathogens will be conducted in a coordinated manner , adopting common standards. To facilitate comparative studies the data obtained in different laboratories will be collected in a common format, and eventually collected in a newly designed database.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencesbiological sciencesmicrobiologybacteriology
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- natural sciencesbiological sciencesgeneticsgenomes
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Call for proposal
Data not availableFunding Scheme
THN - Thematic network contractsCoordinator
53100 SIENA
Italy