Objective
Trypanosoma is a protozoan pathogen endemic to Africa that causes human sleeping sickness and that is among the most important causes of livestock morbidity and mortality in Africa and parts of South America. Due to the current resurgence of the disease an increasing number of EC citizens will be at risk through tourism and business in Africa as well as during humanitarian interventions. The current widespread use of highly toxic drugs for chemoprophylaxis in livestock in Africa and South America may also threaten European consumers. The animal disease is a major factor in rural development in many African countries and has strong impact on their economies and thus their potential as trade partners for the EU. Drugs for safe, effective and inexpensive treatment are not available. Infective forms of Trypanosoma brucei undergo irreversible growth arrest and differentiation at high parasite density in the mammalian bloodstream. A specific arrest in the G0 phase of the cell cycle is mediated by a parasite derived factor that acts via the cAMP signalling pathway. Three apparently non-redundant protein kinase A (PKA) isoforms were identified. Here, a reverse genetic analysis of PKA function is proposed to validate the signalling pathway as a drug target. The regulated phosphorylation and mode of activation of T. brucei PKA that appears to deviate from mammalian PKA will be analysed. Cloning of cell cycle regulators known to be cAMP-modulated in other systems will be attempted.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry sleep disorders
- social sciences sociology demography mortality
- natural sciences biological sciences biochemistry biomolecules proteins
- agricultural sciences animal and dairy science domestic animals animal husbandry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.