Dendrite cell immunobiology is nowadays a cutting edge topic in the development of new vaccine strategies. The mastering of new approaches in the manipulation of the different lineages of these antigen- presenting cells will be fundamental in the next years to reach optimal priming of immune responses. Cross- priming of viral antigens derived from apoptotic debris of infected cells is an important process of exogenous antigen uptake, and it is probably of great relevance in natural infections. Consequently, a deep comprehension of this event is of outstanding interest not only in HIV infection, but also in many infectious diseases In my experience in molecular biology and cell biology of pathogens and immune cells, I'm trained in the basic techniques required for the proposed project. I will find additional training in cellular immunology (human CD8 T cell cloning, dendrite cell culture and isolation), and co focal microscopy. The proposed collaboration with the host institute will probably constitute a good combination of different perspectives that will allow exchange of ideas and good technical complementation. This post-doctoral experience should allow me to apply to a permanent research or teaching position when I return to Andalusia, and later to develop collaborations with French scientists.