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Biosafe coronavirus vaccine vector for the prevention of human infections of the enteric and respiratory tract (BIOSAFE-VACCINE-VECTOR)

Objective

The objective is a comprehensive approach for the treatment and protection against human enteric and respiratory infectious diseases by using a vector based on recently isolated corona virus coda genome that amplifies the gene of interest inducing protection without the production of infectious virus and the development of a transgenic mouse model to test vector efficacy. The vector is produced in packaging cell line that provides an essential component for virus vector replication, missing in the virus genome. Additional bio safety strategies, like the relocation of the genome-packaging signal, will lead to an extremely secure virus vector. The expression system will be applied to the protection against human enteric rotavirus and corona virus causing enteric necrosis in children or respiratory infections in adult.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Address
Campus De La Universidad Autonoma De Madrid
28049 Madrid
Spain

Participants (5)

FORT DODGE VETERINARIA S.A.
Spain
Address
Carretera Camprodon S/n Km 13 Finca "La Riba"
17813 Vall De Bianya
HANNAH RESEARCH INSTITUTE
United Kingdom
Address
Hannah Research Park, Mauchline Road
KA6 5HL Ayr
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
Domaine De Vilvert
78352 Jouy-en-josas
LUDWIG BOLTZMANN GESELLSCHAFT - OESTERREICHISCHE VEREINIGUNG ZUR FOERDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG
Austria
Address
1,Veterinaerplatz
1210 Wien
ROSLIN INSTITUTE (EDINBURGH)
United Kingdom
Address

EH25 9PS Roslin, Midlothian