Biosafe coronavirus vaccine vector for the prevention of human infections of the enteric and respiratory tract (BIOSAFE-VACCINE-VECTOR)

Project Information

BIOSAFE-VACCINE-VECT

Grant agreement ID: QLK2-CT-2001-00874

Project closed

Start date 1 December 2001

End date 27 February 2005

Funded under

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Total cost € 2 632 221,00

EU contribution € 1 255 414,00

Coordinated by

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Objective

The objective is a comprehensive approach for the treatment and protection against human enteric and respiratory infectious diseases by using a vector based on recently isolated corona virus coda genome that amplifies the gene of interest inducing protection without the production of infectious virus and the development of a transgenic mouse model to test vector efficacy. The vector is produced in packaging cell line that provides an essential component for virus vector replication, missing in the virus genome. Additional bio safety strategies, like the relocation of the genome-packaging signal, will lead to an extremely secure virus vector. The expression system will be applied to the protection against human enteric rotavirus and corona virus causing enteric necrosis in children or respiratory infections in adult.

Fields of science

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › health sciences › infectious diseases › RNA viruses › coronaviruses
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• natural sciences › biological sciences › genetics › genomes

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

• EU contribution: No data
• Address: Campus de la Universidad Autonoma de Madrid ; 28049 MADRID ; Spain
• Total cost: No data

Participants (5)

FORT DODGE VETERINARIA S.A.

Spain

• EU contribution: No data
• Address: Carretera Camprodon S/N Km 13 Finca "La Riba" ; 17813 VALL DE BIANYA
• Total cost: No data

HANNAH RESEARCH INSTITUTE

United Kingdom

• EU contribution: No data
• Address: Hannah Research Park, Mauchline Road ; KA6 5HL AYR
• Total cost: No data

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

• EU contribution: No data
• Address: Domaine de Vilvert ; 78352 JOUY-EN-JOSAS
• Total cost: No data

LUDWIG BOLTZMANN GESELLSCHAFT - OESTERREICHISCHE VEREINIGUNG ZUR FOERDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG

Austria

• EU contribution: No data
• Address: 1,Veterinaerplatz ; 1210 WIEN
• Total cost: No data

ROSLIN INSTITUTE (EDINBURGH)

United Kingdom

• EU contribution: No data
• Address: EH25 9PS ROSLIN, MIDLOTHIAN
• Total cost: No data