Objective
The aim of this project is to dissect the cellular basis of immunological memory in. order to provide rationale approach to vaccination, so far only developed on an empirical basis. To this end, we will make use of recently identified memory lymphoid subset markers and recent technological breakthroughs permitting isolation of cells with defined effectors functions and antigen specificities to investigate the mechanisms that generate and maintain different types of memory cells. The relative role of tissue homing effectors memory T cells versus lymph node homing central memory T cells will be studied and the latter will be analysed to identify the cells that in secondary responses serve as precursors for effectors, help B cells, or mediate immune suppression. The analysis will be extended ton on-conventional NK-T and god T cells. The contribution of memory B cells and short-and long-lived plasma cells in protective and reactive memory responses will be analysed. The knowledge acquired through the above in vitro systems will be applied to the assessment of memory responses in vivo in rodent models and in primates immunized with hepatitis C virus-derived antigens. These results are expected to provide new general insights into the mechanisms of immunological memory and to identify immune parameters correlating with protective responses following viral infections.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology mammalogy primatology
- medical and health sciences health sciences infectious diseases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
53100 SIENA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.