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Novel inhibitors of adhesin/receptor interactions involved in microbial infection at mucosal surfaces (ADRI)

Objective

This proposal, involving critical network European scientists, is to investigate a novs approach to the prevention of microbial infection at mussel surfaces, namely, mussel application of molecules that specifically inhibit the attachment of pathogenic microbes. In view of considerable concern over the spread of antibiotic resistance, such an approach is timely. Molecules to be used, as specific inhibitors will be analogues of either the microbial adhesion or the host receptor, antibodies and antibody fragments. We have chosen a viral, a bacterial and a fungal mussel pathogen for each of which adhesions receptors have been well defined and for which there are established relevant animal models. These models will allow in vivo testing of inhibitors, and their modes of delivery, and of compounds witch can boost innate immune clearance mechanisms. The proposal should lead to the development of navel antimicrobials for the prevention and control of human infections and establish a rationale for the development of further antimicrobials.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Cleveland Street 46
W1P 6DB London
United Kingdom

Participants (8)

CARBOHYDRATE SYNTHESIS LIMITED
United Kingdom
Address
Culham Science Centre, Building 15, North Culham E
OX14 3GY Abingdon
DOMANTIS LIMITED
United Kingdom
Address
Granta Park
CB1 6G5 Cambridge
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma
KAROLINSKA INSTITUTE
Sweden
Address

141 57 Huddinge
KING'S COLLEGE LONDON
United Kingdom
Address
Floor 28, Guy's Tower, Guy's Hospital, St Thomas S
SE1 9RT London
UNILEVER NEDERLAND BV
Netherlands
Address
120,Olivier Van Noortlaan 120
3133 AT Vlaardingen
UNIVERSITY OF UMEAA
Sweden
Address

901 87 Umeaa
UNIVERSITÀ DEGLI STUDI DI SIENA
Italy
Address
Viale Bracci Policlinico Dellle Scotte
53100 Siena