Objective
The ultimate goal is the design of new antiviral drugs that specifically interfere with the replication of virus members of the Mononegavirales order, which are responsible for human and animal life-threatening diseases with large socio-economic impact. The RNA-dependent RNA-polymerise (Drip) of these viruses, the replicas, has no counterpart in mammalian cells, what makes it an attractive target for antiviral therapy. Seven partners will perform a structure-function analysis of the replicas, its viral, and possibly cellular, cofactors, and of its unique template, the nucleocapsid, in the presence or absence of antiviral drugs. To increase the chance of success, three complementary virus models will be studied, the Measles, Respiratory Syncytial & Sendai viruses. The outcome will be a "poly-erase toolbox' which will enable a panel of 5 European SME to model the replicas and its template from any related viruses and design new antiviral drugs & vaccine.
Fields of science
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contracts
Coordinator
69622 Villeurbanne
France
See on map
Participants (9)
91198 Gif-sur-yvette
See on map
13402 Marseille
See on map
75794 Paris
See on map
28220 Majadahonda
See on map
3000 Louvain / Leuven
See on map
G11 5JR Glasgow
See on map
13007 Marseille
See on map
1211 Geneve
See on map
13331 Marseille
See on map