Towards the design of new potent antiviral drugs: structure-function analysis of paramyxoviridae rna polymerase (VIRRNAPOLDRUGTARGET)

Objective

The ultimate goal is the design of new antiviral drugs that specifically interfere with the replication of virus members of the Mononegavirales order, which are responsible for human and animal life-threatening diseases with large socio-economic impact. The RNA-dependent RNA-polymerise (Drip) of these viruses, the replicas, has no counterpart in mammalian cells, what makes it an attractive target for antiviral therapy. Seven partners will perform a structure-function analysis of the replicas, its viral, and possibly cellular, cofactors, and of its unique template, the nucleocapsid, in the presence or absence of antiviral drugs. To increase the chance of success, three complementary virus models will be studied, the Measles, Respiratory Syncytial & Sendai viruses. The outcome will be a "poly-erase toolbox' which will enable a panel of 5 European SME to model the replicas and its template from any related viruses and design new antiviral drugs & vaccine.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITE CLAUDE BERNARD LYON 1

Address

Boulevard Du 11 Novembre 1918, 43
69622 Villeurbanne
France

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Avenue De La Terrasse 14
91198 Gif-sur-yvette

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

31,Chemin Joseph Aiguier 31
13402 Marseille

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Rue Michel Ange 3
75794 Paris

INSTITUTE OF HEALTH CARLOS III

Spain

Address

Carretera De Majadahonda A Pozuelo
28220 Majadahonda

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

Address

Oude Markt 13
3000 Louvain / Leuven

MEDICAL RESEARCH COUNCIL

United Kingdom

Address

Church Street
G11 5JR Glasgow

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

France

Address

Boulevard Charles Livon 58
13007 Marseille

UNIVERSITY OF GENEVA

Switzerland

Address

1,Avenue De Champel 9
1211 Geneve

UNIVERSITÉ DE PROVENCE, AIX-MARSEILLE

France

Address

Place Victor Hugo 3
13331 Marseille