Skip to main content

Towards the design of new potent antiviral drugs: structure-function analysis of paramyxoviridae rna polymerase (VIRRNAPOLDRUGTARGET)

Objective

The ultimate goal is the design of new antiviral drugs that specifically interfere with the replication of virus members of the Mononegavirales order, which are responsible for human and animal life-threatening diseases with large socio-economic impact. The RNA-dependent RNA-polymerise (Drip) of these viruses, the replicas, has no counterpart in mammalian cells, what makes it an attractive target for antiviral therapy. Seven partners will perform a structure-function analysis of the replicas, its viral, and possibly cellular, cofactors, and of its unique template, the nucleocapsid, in the presence or absence of antiviral drugs. To increase the chance of success, three complementary virus models will be studied, the Measles, Respiratory Syncytial & Sendai viruses. The outcome will be a "poly-erase toolbox' which will enable a panel of 5 European SME to model the replicas and its template from any related viruses and design new antiviral drugs & vaccine.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITE CLAUDE BERNARD LYON 1
Address
Boulevard Du 11 Novembre 1918, 43
69622 Villeurbanne
France

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Avenue De La Terrasse 14
91198 Gif-sur-yvette
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
31,Chemin Joseph Aiguier 31
13402 Marseille
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
75794 Paris
INSTITUTE OF HEALTH CARLOS III
Spain
Address
Carretera De Majadahonda A Pozuelo
28220 Majadahonda
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
3000 Louvain / Leuven
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Church Street
G11 5JR Glasgow
UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II
France
Address
Boulevard Charles Livon 58
13007 Marseille
UNIVERSITY OF GENEVA
Switzerland
Address
1,Avenue De Champel 9
1211 Geneve
UNIVERSITÉ DE PROVENCE, AIX-MARSEILLE
France
Address
Place Victor Hugo 3
13331 Marseille