Objective Pregnancy-associated malaria can cause infant mortality, premature delivery, low birth weight and anaemia and death in the mother. It is a major global public health problem. Our RTD project emphasises the development of a vaccine to protect pregnant women and their newborns from the adverse effects of malarial infections. We will carry out an extensive characterisation of the complex phenomenon of parasite adhesion and sequestration in the placenta, through which we hope to identify parasite protein antigen domains responsible for binding of infected erythrocytes. We will determine the functional relevance of receptor-ligand interactions and will generate structural information to facilitate the development of anti-adhesion vaccines. We will also focus on elucidating the immune mechanisms involved in protection, identifying anti-parasite antibodies and evaluating cytokine production in the placenta in response to malarial infections. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health scienceshealth sciencespublic healthsocial sciencessociologydemographymortalitymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesclinical medicineobstetrics Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator BERNHARD NOCHT INSTITUT FUER TROPENMEDIZIN EU contribution No data Address Bernhard-Nocht-Strasse 74 20359 HAMBURG Germany See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all COPENHAGEN UNIVERSITY HOSPITAL Denmark EU contribution No data Address 20,Tagensvej 20 2200 N KOEPENHAGEN See on map Total cost No data INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT France EU contribution No data Address Avenue de l'Observatoire 4, FacultT des Sciences P 75270 PARIS See on map Total cost No data INSTITUT PASTEUR France EU contribution No data Address Rue du Docteur Roux 25 75724 PARIS See on map Total cost No data KAROLINSKA INSTITUTE Sweden EU contribution No data Address 13,Nobels väg 16 171 77 Stockholm See on map Total cost No data THE UNIVERSITY OF TUEBINGEN Germany EU contribution No data Address Wilhelmstrasse 27 72074 TUEBINGEN See on map Total cost No data UNIVERSITY OF EDINBURGH United Kingdom EU contribution No data Address West Mains Road, Ashworth Laboratories, King's Bu EH9 3JT EDINBURGH See on map Total cost No data