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The development of a vaccine against pregnancy-associated malaria

Objective

Pregnancy-associated malaria can cause infant mortality, premature delivery, low birth weight and anaemia and death in the mother. It is a major global public health problem. Our RTD project emphasises the development of a vaccine to protect pregnant women and their newborns from the adverse effects of malarial infections. We will carry out an extensive characterisation of the complex phenomenon of parasite adhesion and sequestration in the placenta, through which we hope to identify parasite protein antigen domains responsible for binding of infected erythrocytes. We will determine the functional relevance of receptor-ligand interactions and will generate structural information to facilitate the development of anti-adhesion vaccines. We will also focus on elucidating the immune mechanisms involved in protection, identifying anti-parasite antibodies and evaluating cytokine production in the placenta in response to malarial infections.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

BERNHARD NOCHT INSTITUT FUER TROPENMEDIZIN
Address
Bernhard-nocht-strasse 74
20359 Hamburg
Germany

Participants (6)

COPENHAGEN UNIVERSITY HOSPITAL
Denmark
Address
20,Tagensvej 20
2200 N Koepenhagen
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
France
Address
Avenue De L'observatoire 4, Facultt Des Sciences P
75270 Paris
INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 25
75724 Paris
KAROLINSKA INSTITUTE
Sweden
Address
13,Nobels Väg 16
171 77 Stockholm
THE UNIVERSITY OF TUEBINGEN
Germany
Address
Wilhelmstrasse 27
72074 Tuebingen
UNIVERSITY OF EDINBURGH
United Kingdom
Address
West Mains Road, Ashworth Laboratories, King's Bu
EH9 3JT Edinburgh